Evolution of Transposons Containing bla TEM Genes
نویسندگان
چکیده
منابع مشابه
A bla(TEM-1b)-derived TEM-6 beta-lactamase: a case of convergent evolution.
Since the first communication describing an organism that produces an enzyme capable of hydrolyzing extended-spectrum cephalosporins (5, 6), several outbreaks of Enterobacte-riaceae resistant to oxyimino--lactams have been reported. In these cases, the adopted survival strategy of bacteria challenged by the introduction of aztreonam, cefotaxime, ceftazi-dime, and other oxyimino--lactams was t...
متن کاملUpdated sequence information and proposed nomenclature for bla(TEM) genes and their promoters.
The nucleotide sequences of 59 bla(TEM) genes encoding inhibitor-resistant TEM enzymes showed great genetic variability and were associated with different types of promoters. These findings led us to suggest an updated bla(TEM) gene nomenclature based on the origin of the bla(TEM) gene (bla(TEM-1A), bla(TEM-1B), bla(TEM-1C), bla(TEM-1D), bla(TEM-1E), and bla(TEM-1F)) and the promoter type.
متن کاملdetection of bla tem and bla shvgenes among clinical isolates of e. coli from tehran hospitals
background and objectives: the pathogenic strains of escherichia coli cause severe septicemia, urinary tract infection and wound sepsis. resistance of this organism to the expanded-spectrum cephalosporins occurs via the production of extended-spectrum β-lactamases (esbls) such as tem and shv. these enzymes hydrolyze oxyimino cephalosporins (cefotaxime, ceftazidime) and monobactams (aztreonam). ...
متن کاملfrequency of bla tem, bla shv, bla ctx-m, and qnra among escherichia coli isolated from urinary tract infection
conclusions considering the high prevalence of esbl genes (bla ctx-m, 87%; and bla tem, 82%), fluoroquinolones may be used as an alternative drug in treatment, although resistance to this family is increasing as well. as a result, this increasing trend should be prevented using appropriate guidelines for prescription. background escherichia coli is the most important as well as the most common ...
متن کاملPromoters P3, Pa/Pb, P4, and P5 upstream from bla(TEM) genes and their relationship to beta-lactam resistance.
Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter P5, only found upstream of the bla(TEM-1B) gene, was related to the highest e...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2005
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.49.3.1267-1268.2005